BATWatch is an independent research and data collaboration studying biological clearance mechanisms in the human brain, including the relationships between Beta-Amyloid, Tau, metabolic rhythms, and long-term cognitive resilience.
BAT Levels show how well your brain clears and repairs itself, years before symptoms. Think A1C for blood sugar or cholesterol for the heart. BATScore turns validated lab signals into one number you can track over time, for prevention and planning, not diagnosis.
Our Vision
Make proactive brain health routine for every adult, with simple annual checks, optional short resets when trends drift, and clear data people can understand.
Our Mission
Track early biological signals that matter, beta amyloid and tau with supporting markers like cholesterol and inflammation, then guide smart next steps with licensed clinical oversight where applicable.
Our Process
Test, interpret, act, and verify. Start with annual BATCheck, review BATScore in context, consider a short BATReset cycle only if drift persists, then recheck on a 3 to 12 month schedule to confirm trend.
BATWatch Research Series: Foundational Papers in Preventive Neuroscience
This section houses the official BATWatch Research Group publications archived on Zenodo, representing the scientific foundation of the BAT Framework, including BAT Levels, BATScore, BATReset, and related preventive neuroscience concepts.
This white paper introduces a proposed real-world framework for non-invasive brain clearance monitoring, extending plasma-based biomarker testing beyond traditional cerebrospinal fluid (CSF) diagnostics. The BAT Testing and BATCheck system is designed for preventive neuroscience applications, integrating validated biomarkers of Beta-Amyloid (Aβ) and Tau (T) with contextual metabolic and inflammatory indicators. The observations described are based on early, de-identified registry data and are not yet peer-reviewed. This model aims to demonstrate the feasibility of large-scale clearance monitoring, not to claim clinical efficacy. The BAT Testing and BATCheck framework extends this evolution into real-world preventive neuroscience, integrating validated assays for Beta-Amyloid (Aβ) and Tau (T) proteins with contextual metabolic, inflammatory, and hormonal markers. This paper outlines how BAT Testing measures molecular clearance efficiency while BATCheck identifies upstream systemic influences that modulate that efficiency. Together, they operationalize Clearance Monitoring, a measurable biological rhythm rather than a diagnostic endpoint. Positioned alongside World Health Organization (WHO), National Institutes of Health (NIH), and Centers for Disease Control and Prevention (CDC) priorities for dementia prevention, this framework demonstrates that clearance dynamics can be tracked, stabilized, and analyzed across populations without reliance on invasive procedures. The framework builds upon a peer-reviewed foundation of validated plasma biomarker research, translating those findings into a scalable, real-world preventive model.Reference:
BATWatch Research Group (2025). Quantifying Brain Clearance Through BAT Testing and BATChecks. (Version 2.0) Zenodo. http://doi.org/10.5281/zenodo.17755189
BATScore is a longitudinal index developed by BATWatch Research Group (TeamBrain, Inc.) to quantify brain clearance efficiency over time. Derived primarily from BAT Levels, it integrates contextual adjustments from systemic inflammatory markers (e.g., hs-CRP, IL-6) and validated metabolic indicators (e.g., fasting glucose, insulin sensitivity) that reflect transient clearance pressure. Observational data from the BATWatch Registry (over 3,000 participants, 10,000+ data points) demonstrate that BATScore trajectories are stable within individuals and sensitive to clearance rhythm disruptions, making it a promising candidate for population-scale preventive neuroscience. This publication presents the conceptual framework, validation approach, and interpretive model for BATScore, while maintaining confidentiality of quantitative weighting and computational methods under the BAT Framework.Reference:BATWatch Research Group (2025). BATScore: The Longitudinal Metric of Clearance Efficiency. (Version 2.0) Zenodo. http://doi.org/10.5281/zenodo.17755094
BATophagy represents the targeted activation of autophagy and glymphatic clearance to remove Beta-Amyloid (Aβ) and Tau (T) proteins from the brain. Unlike passive measurement frameworks, BATophagy focuses on inducing biological cleanup using natural and clinical pathways that support neuronal renewal, reduce protein aggregation, and restore metabolic and circadian balance. This paper defines BATophagy as a functional mechanism for brain maintenance, describes its activation through behavioral, nutritional, and pharmacological methods, and outlines its integration within BATReset, a structured program that synchronizes cellular recycling and brain-wide clearance. By tracking outcomes through BAT Levels and BATScore, the BATWatch Registry provides early real-world evidence that BATophagy can be stimulated and maintained across time, turning prevention into a measurable biological process.Reference:BATWatch Research Group (2025). BATophagy: Inducing Beta-Amyloid and Tau Clearance Through Biological Autophagy and Brain Flow. (Version 2.0) Zenodo. https://doi.org/10.5281/zenodo.17755218
The decline in biological clearance rhythm... known as biological drift... represents a measurable loss of efficiency in the body’s ability to recycle and remove Beta-Amyloid (Aβ) and Tau (T). TheBATReset Protocol was developed to re-establish that rhythm through structured behavioral and metabolic recalibration. Unlike treatment regimens that target pathology, BATReset operates upstream, helping re-stabilize the cellular and metabolic environment that supports BATophagy, the natural process of brain cleanup. This paper outlines the conceptual framework of BATReset, summarizes preliminary registry observations, and positions the program as a model for measurable prevention... emphasizing rhythm restoration, not medication or disease modification.ReferenceBATWatch Research Group, 2025. BATReset, Structured Biological Restoration Through Clearance Rhythm Re stabilization. (Version 2.0) Zenodo.
https://doi.org/10.5281/zenodo.17755209
While BATophagy represents the targeted clearance of Beta-Amyloid (Aβ) and Tau (T) proteins, its efficiency depends on foundational lifestyle-supported autophagy and glymphatic pathways. This paper explores how sleep architecture, metabolic rhythm, movement patterns, stress modulation, and inflammation control create the biological conditions required for effective BAT clearance. Observational data from the BATWatch Registry demonstrate that these behavioral levers, when consistently applied, correlate with stabilized BATScore trajectories and reduced biological drift.Reference:BATWatch Research Group (2025). Lifestyle Modulation of Clearance Rhythm: Supporting BATophagy Through Autophagy and Glymphatic Activation. (Version 2.0) Zenodo. http://doi.org/10.5281/zenodo.17755176
This paper defines Clearance Efficiency as a quantifiable biological rhythm reflecting the brain’s capacity to regulate and clear Beta-Amyloid (Aβ) and Tau (T) proteins, processes essential to sustaining long-term cognitive resilience. The BATWatch Quantitative Prevention Model operationalizes this concept through four integrated components, BAT Testing, BATCheck, BATReset, and BATScore, forming a closed-loop framework that unites biomarker measurement, biological rhythm stabilization, and registry-based analytics. Aligned with the World Health Organization (WHO) dementia-prevention framework, the National Institutes of Health (NIH) translational biomarker strategy, and the Centers for Disease Control and Prevention (CDC) Healthy Brain Initiative, this model reframes brain health as a measurable, maintainable system rather than a reactive response to disease. Rooted in Preventive Neuroscience, the framework provides a population-level model for early detection, stabilization, and monitoring of biological drift, enabling healthcare systems to transition from reactive neurology to proactive biological maintenance.Reference:
BATWatch Research Group (2025). The Public Health Value of Measuring Brain Clearance Efficiency: A Quantitative Prevention Model. (Version 2.0) Zenodo. http://doi.org/10.5281/zenodo.17755196
